RetroVector

BioVec Pharma has established a strong platform that enables the efficient production of high-titer retroviral vectors in suspension culture and serum-free media
 
Summary
There is an increasing demand for the development of safe and efficient retroviral vectors production systems. BioVec Pharma's RetroVector technology is based on the HEK293 cell line (293Vec-AmphoTM, 293Vec-GalvTM and 293Vec-RD114TM) that can produce high yields of retroviral vectors in suspension and serum-free media. It is one of the most efficient retroviral production systems currently available, which has many applications in medicine, product development and discovery research.
 
Concept
Gene therapy is a developing technology that promises to revolutionize medical practice; it involves the transfer of genetic material into patient’s cells in order to provide a therapeutic benefit to that patient. The retroviral vector is the system of choice for many gene-based treatments addressing inherited and acquired diseases. However, packaging cell lines currently used for the production of recombinant retroviruses lack some safety features, and scale-up cannot be easily achieved for clinical trials with a large number of patients. BioVec Pharma packaging cell lines have been adapted to suspension culture and to serum-free media. The suspension culture is compatible with the production of large amounts of retroviral vectors in bioreactors, opening the possibility for large-scale use of retroviral vectors in late stage clinical trials. Serum-free media have several market advantages: a better definition of the media composition, reduced risks of contamination by adventitious and infectious agents, and lower cost. It is a clear advantage for the production of clinical vector batches in GMP conditions.
 
Applications
• Large-scale transient or stable production of retroviral vectors in suspension and under serum-free conditions.
• Screening and optimization of serum-free media.
 
 
 
 



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